Caroline J Zeiss, PhD, DACVP, DACLAM

Professor of Comparative Medicine and Associate Professor of Ophthalmology and Visual Science; Director, Mouse Research Pathology Core; Unit Chief, Pathology

Research Interests

Animal Diseases; Neuroanatomy; Neurobiology; Ophthalmology; Pathologic Processes; Primates; Neurodegenerative Diseases; Informatics; Translational Medical Research

Research Organizations

Comparative Medicine


Faculty Research

Office of Cooperative Research

Research Summary

Why do so many promising animal studies fail to translate to successful treatments for humans? Our lab uses biomedical informatics to identify large scale patterns of animal model. This approach reveals systemic biases in the utilization of animal models that contribute to the translational gap. In particular, we are interested in methods that can correlate interventional outcomes across human and animal species by intervention, drug class and choice of outcome measure. We focus on chronic and complex diseases, in particular neurodegenerative disease. This focus is informed by extensive animal models experience using small and large animal models of retinal and neurodegenerative disease.

Specialized Terms: Biomedical informatics; Efficacy; Translational gap; Neurodegeneration; Neurobiology of movement disorders; Phenotypes of genetically engineered mice; Evolutionary biology of the eye; Veterinary Pathology; Mouse Phenotyping; Ocular pathology; Neuroanatomy of age-related gait disorders;

Selected Publications

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Contact Info

Caroline J Zeiss, PhD, DACVP, DACLAM
Mailing Address
Comparative MedicinePO Box 208016
New Haven, CT 06520-8016